Findings from both mice and rabbits predicted the response to patients and is a testament to the value of laboratory animal models for defining new treatments for lethal untreatable human infectious diseases. USA.gov. Eleven short video case studies explore research integrity topics in a fictional but very relatable laboratory. The videos are followed by … However, not all animals sharing a common pasture become obese and/or insulin resistant and some ponies develop laminitis in the absence of either factor. Research integrity and misconduct: first-hand experiences of plagiarism and data manufacture. Finally we now understand the immune response that chickens make to Campylobacter may be exploited by some forms of vaccination and we are working with a vaccine company to develop these vaccines. Biased Peer Review or Flawed Methodology? Research Value in the Post-MiFID II World RELEASED DECEMBER 2017 So reducing the levels in chicken flocks should lead to a reduction in human cases. Currently around 70% of leisure horses are overweight or obese. Separate purchase: ResearchFocus®: 2018 Research Pricing Study RELEASED APRIL 2019. You Suspect Research Misconduct. Research, Scholarship, and Creative Activities are integral to being an academician. As part of a community of scholars, we share our research and build upon the work of one another. (PDF). A research team from a prominent laboratory published an article in a prestigious academic journal. Previously it was thought that the bacteria lived in one part of the chicken gut called the caeca, but we know that some variants can survive through the full length of the gastrointestinal system. A series to raise awareness, encourage dialog and inspire creative problem solving for challenges in maintaining integrity in peer review. Get the latest research from NIH: https://www.nih.gov/coronavirus. What happens when a former colleague contacts you, a reviewer, out of the blue to ask if the application on which he is a principal investigator could be treated favorably at the review meeting? COVID-19 is an emerging, rapidly evolving situation. Office of Research Integrity ~ 1101 Wootton Parkway ~ Suite 240 ~ Rockville MD 20852, Now Playing:Choosing the Right Lab (2:52), To Proceed or Not to Proceed Without Raw Data? Without this evidence, the clinical trials are too risky to conduct and cannot proceed. We also use cultured chicken cells, the waxworm (Galleria melonella) insect infection model and mathematical modelling approaches which has allowed us to use fewer animals in better designed experiments but ultimately most of our work requires the complexity of the whole animal. Am J Trop Med Hyg. Switchboard: +44 (0)151 794 2000 Student enquiries: +44 (0) 151 794 5927, Resources and guidance on research integrity. Reproducibility or Luck? Epub 2017 Mar 20. The Struggle to Get Results (3:46), To Proceed or Not to Proceed Without Raw Data? (4:07) Each case is categorized according to the year in which ORI closed the case. Clipboard, Search History, and several other advanced features are temporarily unavailable. Unlike many experimental systems we are not trying to model a human disease, but are re-creating what happens on farms in a controlled and contained environment. Cryptococcal meningitis is a rapidly lethal fungal infection that involves the brain and the lining of brain. Case Studies The following cases are anonymized, but based on real events. What happens when the NIH discovers that an investigator has embellished his or her credentials in an NIH grant application? RESEARCH, as used on this site, refers to research and scholarship across all disciplinary fields from the Arts and Humanities to the Sciences. He and his wife are expecting their first child soon. These concerns have been matched by an ‘owner-led’ demand for improved nutritional management of senior (older than 20 years) and obese (body condition score more than 7/9) animals. Ashley is a graduate student seeking to join a lab. Case study: PERIL analysis of a funding opportunity limited by conditions imposed by a collaborating organisation A residential rehabilitation charity approaches you to collaborate in an application to fund doctoral research into the long-term effect of its project. The administration of amphotericin B for a prolonged period is infeasible in the health care settings where cryptococcal meningitis is most frequent. In conclusion, plagiarism seems to be widespread in resource-limited settings and a greater response with educational and zero-tolerance components is needed to prevent it. Embellished Credentials in a Grant Application: A Case Study Research and response This case study is an exemplar of the use of laboratory animal models to provide the vital underpinning evidence for clinical trials. Now What? A RESEARCHER broadly includes all who contribute to the process of research according to the standards in their field. It was considered a breakthrough paper that answered a major question in a scientific field. These case study videos address topics such as mentoring relationships, authorship, publication, data integrity, and potential research misconduct. Papers produced in a laboratory normally list many people in the laboratory as authors, but the first named author is the primary person responsible for the paper. These case study videos address topics such as mentoring relationships, authorship, publication, data integrity, and potential research misconduct. Crossing the Line into Misconduct (3:45) We have studied two formulations of amphotericin B: amphotericin B deoxycholate and liposomal amphotericin B. Experience the issues that arise from being in a small lab through the eyes of a new principal investigator (PI), a postdoctoral fellow, and a graduate student. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Linked studies have allowed us to explore variation in the glycaemic response of ponies to different feedstuffs. Horse and pony owners are acutely aware of the challenges of both maintaining body weight in elderly animals and minimizing the risk of laminitis in obese ponies. Plagiarism is a serious, yet widespread type of research misconduct, and is often neglected in developing countries. In this context, we present a longitudinal case study of seven instances of plagiarism and cheating arising in four consecutive classes (2011-2014) of an Epidemiology Masters program in Lima, Peru, and describes the implementation and outcomes of a multifaceted, "zero-tolerance" policy aimed at introducing research integrity. A RESEARCHER broadly includes all who contribute to the process of research according to the standards in their field. | The charity reports that it has been involved in research previously and has found it beneficial. Now What? A series to raise awareness, encourage dialog and inspire creative problem solving for challenges in maintaining integrity in peer review. Follow the story of Dr. Thompson's laboratory. These conditions are recognised as the major welfare challenges facing domestic horses and ponies. Urol Oncol. important documents relating to graduate students, Listing of academic programs, policies and related, Doctoral students pursue studies at other BTAA institutions, Graduate Departments review applicants based on their criteria, Important Information about the graduate application process, Application information specific to international students. (4:08), Reproducibility or Luck? What can be done to Promote Research Integrity? Get the latest public health information from CDC: https://www.coronavirus.gov. COVID-19 is an emerging, rapidly evolving situation. The situation is complex and ‘simple solutions’ such as ‘feeding the horse more or less’ are far from simple to effect under domestic conditions, without causing further negative impacts on health. Ultimately, she joins Dr. Thompson's lab where she hopes to receive more individual attention. Dr. Thompson relies on him to mentor graduate students with which he has little experience. When the core values of peer review are compromised, funding decisions may be based on improper or inaccurate information; proprietary information may be compromised; the public may lose trust in science; and patients in clinical studies may be harmed. To Proceed or Not to Proceed Without Raw Data? In this context, we present a longitudinal case study of seven instances of plagiarism and cheating arising in four consecutive classes (2011-2014) of an Epidemiology Masters program in Lima, Peru, and describes the implementation and outcomes of a multifaceted, "zero-tolerance" policy aimed at introducing research integrity. RESEARCH broadly includes the exploration, discovery, interpretation, revision, and sharing of knowledge of our world, including the creation of works for the enlightenment and intellectual stimulation of humans. We used well-characterised laboratory animal models of cryptococcal meningitis in mice and rabbits to test this idea. We were able to show that infection leads to poor gut health which in turn leads to poorer welfare of the animal. We use our case studies when giving lectures or standalone training sessions on research integrity, when we contribute to research institutions’ education and development programmes, and at UKRIO’s own events. Now What? Some animals are relatively weight loss resistant and may require severe ‘dieting’ under veterinary supervision in order to lose weight. In this context, we present a longitudinal case study of seven instances of plagiarism and cheating arising in four consecutive classes (2011-2014) of an Epidemiology Masters program in Lima, Peru, and describes the implementation and outcomes of a multifaceted, "zero-tolerance" policy aimed at introducing research integrity. Without this evidence, the clinical trials are too risky to conduct and cannot proceed. This page contains cases in which administrative actions were imposed due to findings of research misconduct. This disease causes approximately 600,000 deaths per year, with most cases in low to middle income countries in Africa and South East Asia. U.S. Department of Health and Human Service Preliminary results from patients with cryptococcal meningitis receiving a single shot of amphotericin B appeared to be the same as patients receiving the standard daily therapy. In Europe it is estimated 1 in every 100 people are infected with Campylobacter each year and that most of these cases are from infected poultry meat. Two cases involved cheating in graded assignments, and five cases …
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